April 1986

Preleukemia Manifested by Hemolytic Anemia With Pyruvate-Kinase Deficiency

Author Affiliations

From the Hematology Department, Hadassah University Hospital and the Hebrew University Medical School, Jerusalem. Dr Kornberg is presently with the Department of Hematology, Assaf-Harofeh (Israel) Medical Center.

Arch Intern Med. 1986;146(4):785-786. doi:10.1001/archinte.1986.00360160237030

• A 27-year-old patient manifested severe hemolytic anemia during a preleukemia phase. Low levels of adenosine triphosphate and decreased activity of pyruvate kinase were found. Acute myeloblastic leukemia developed in this patient 20 months later. The case suggests that acquired enzyme deficiency may play a role in the development of anemia in the preleukemic state.

(Arch Intern Med 1986;146:785-786)