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We thank Dr Stark very much for his comments on our article. His hypothesis is interesting, but I cannot thoroughly accept his hypothesis for the following reason.
Captopril is now widely used throughout the world, but, to our knowledge, the reports of cough during treatment with low-dose captopril are very few. We think, therefore, that there is a discrepancy between his hypothesis and the rare occurrence of cough during therapy with low-dose captopril.
Sesoko S, Kaneko Y. Mechanism of Cough With Angiotensin-Converting Enzyme Inhibition-Reply. Arch Intern Med. 1986;146(6):1227. doi:10.1001/archinte.1986.00360180247046