July 1986

Hemorrhagic Cystitis Associated With Adenovirus Infection in Bone Marrow Transplantation

Author Affiliations

From the Oncology Center and the Division of Clinical Microbiology, The Johns Hopkins Medical Institutions, Baltimore.

Arch Intern Med. 1986;146(7):1400-1401. doi:10.1001/archinte.1986.00360190186026

• A retrospective study of bone marrow transplant recipients shedding adenovirus type 11 in the urine was carried out to determine the association between viral shedding and hemorrhagic cystitis in this population. Weekly urine virology surveillance cultures were obtained during the first 100 days following transplantation. Adenovirus type 11 was cultured from five of 502 bone marrow transplant recipients from 1977 through 1984. In four of these five patients there was associated hemorrhagic cystitis. This contrasts with an overall incidence of hemorrhagic cystitis of 20% in this bone marrow transplant population. A case of hemorrhagic cystitis occurred in a patient following bone marrow transplantation. Recognition of a viral origin of hemorrhagic cystitis may explain the occurrence of late hemorrhagic cystitis in patients despite interventions designed to prevent cyclophosphamideinduced hemorrhagic cystitis. Hemorrhagic cystitis may be the presenting sign of a lethal adenoviral infection.

(Arch Intern Med 1986;146:1400-1401)