August 1986

Prevention of Amphotericin B—Induced Rigors by Dantrolene

Author Affiliations

From the Departments of Pharmacy (Dr Gross) and Medicine (Drs Fulkerson and Moore), Duke University Medical Center, Durham, NC.

Arch Intern Med. 1986;146(8):1587-1588. doi:10.1001/archinte.1986.00360200157025

• Three patients had severe amphotericin B—induced rigors refractory to conventional prophylactic measures. Rigors improved or disappeared when dantrolene sodium was given prophylactically or during an episode. These observations suggest that dantrolene is useful as an alternative or adjuvant agent for severe rigors associated with amphotericin B infusion.

(Arch Intern Med 1986;146:1587-1588)