• Severe prolonged hypotension developed in a hypertensive patient several hours after the initial doses of minoxidil therapy. Hemodynamic measurements revealed a markedly low systemic vascular resistance and a markedly high cardiac output. Other causes of hypotension were ruled out. The patient's hemodynamic abnormalities lasted three days after minoxidil therapy was discontinued, and she then reverted to hypertension. Thus, a 10-mg starting dose of minoxidil may produce profound life-threatening hypotension, which can last up to 72 hours.
(Arch Intern Med 1986;146:2075-2076)
Allon M, Hall WD, Macon EJ. Prolonged Hypotension After Initial Minoxidil Dose. Arch Intern Med. 1986;146(10):2075-2076. doi:10.1001/archinte.1986.00360220257042