October 1986

Prolonged Hypotension After Initial Minoxidil Dose

Author Affiliations

From the Division of Hypertension (Dr Hall) and the Division of Nephrology (Drs Allon and Macon), Department of Medicine, Emory University School of Medicine, Atlanta.

Arch Intern Med. 1986;146(10):2075-2076. doi:10.1001/archinte.1986.00360220257042

• Severe prolonged hypotension developed in a hypertensive patient several hours after the initial doses of minoxidil therapy. Hemodynamic measurements revealed a markedly low systemic vascular resistance and a markedly high cardiac output. Other causes of hypotension were ruled out. The patient's hemodynamic abnormalities lasted three days after minoxidil therapy was discontinued, and she then reverted to hypertension. Thus, a 10-mg starting dose of minoxidil may produce profound life-threatening hypotension, which can last up to 72 hours.

(Arch Intern Med 1986;146:2075-2076)