October 1986

Chest Pain Associated With Mitral Valve Prolapse-Reply

Arch Intern Med. 1986;146(10):2085. doi:10.1001/archinte.1986.00360220267050

The clinical observations by Dr Sataline describing the association of irritable bowel syndrome with mitral valve prolapse syndrome are indeed interesting, and support the concept that esophageal dysmotility may be a component of a more generalized disturbance of gastrointestinal motility in these patients.

We have also recently published a prospective evaluation of 14 patients with mitral valve prolapse and chest pain studies with esophageal manometry and provocative esophageal testing.1 Twelve patients had manometric abnormalities that could explain their chest pain, and approximately 25% had reproduction of their chest pain by Tensilon or Bernstein acid infusion. Six patients with mitral valve prolapse and no chest pain had normal esophageal motility. The findings of our studies when corroborated by other independent observers certainly encourage further research in this area.

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