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November 1986

Intensive Hospital Monitoring Study of Intravenous Cimetidine

Author Affiliations

From the Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Waltham, Mass (Ms Porter, Drs Beard, Walker, and Jick), the Department of Epidemiology, Harvard School of Public Health, Boston (Dr Walker), the Royal Infirmary, Glasgow, Scotland (Dr Lawson), and Auckland (New Zealand) Hospital (Dr Kellaway).

Arch Intern Med. 1986;146(11):2237-2239. doi:10.1001/archinte.1986.00360230177025

• We studied the frequency of adverse reactions occurring in 1189 patients who received cimetidine intravenously, based on data collected as part of a hospital-based monitoring study of recently marketed drugs. There were 40 patients (3.4%) with adverse reactions, 23 of whom were considered to be "definitely" or "probably" related to cimetidine use and 17 patients in whom a causal association was possible. The most frequently reported reactions were neuropsychiatric disorders in 19 patients (1.6%) and leukopenia in eight patients (0.7%).

(Arch Intern Med 1986;146:2237-2239)