November 1986

Hand-Mirror-Cell Variant of B-Cell Lymphoma With Hypercalcemia

Author Affiliations

From the Department of Medicine, Section of Hematology-Oncology, The Medical College of Wisconsin, Milwaukee.

Arch Intern Med. 1986;146(11):2273-2274. doi:10.1001/archinte.1986.00360230219031

• The first (to my knowledge) case of confirmed hand-mirror cell (HMC) non-Hodgkin's lymphoma is described in a 56-year-old white woman. Surface-marker analysis indicated that the cells were B cells with surface IgM (λ). The HMC phenomenon was considered to be real since it was seen on both Wright-Giemsa and supravital stains. In addition, this patient had uncontrollable hypercalcemia and unusual bone-scan findings. The significance of HMC and hypercalcemia in non-Hodgkin's lymphoma is discussed.

(Arch Intern Med 1986;146:2273-2274)