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January 1987

Listeria monocytogenes and the Acquired Immunodeficiency Syndrome

Author Affiliations

New York

East Orange, NJ

Arch Intern Med. 1987;147(1):176. doi:10.1001/archinte.1987.00370010174039

To the Editor.  —The observations of Jacobs and Murray1 in the July issue of the Archives concerning the absence of Listeria monocytogenes in the acquired immunodeficiency syndrome (AIDS) generate interest in the curious absence of expected comorbidity in AIDS. Two diseases, chronic active hepatitis (CAH) and membranoproliferative glomerulonephritis (MPGN), are examples. There is only one case report (to our knowledge) of CAH and AIDS in the world literature,2 even though the hepatitis B surface antigen is frequent in populations at risk for AIDS.3 Although MPGN is commonly seen in heroin-induced nephropathy,4 it is distinctly rare in patients with AIDS.5-7Jacobs and Murray address genetic influences and immune mechanisms in discussing microbial infections in AIDS; notably, the postulated decreased expression of class II histocompatibility gene products, and the possibility that a T-cell subset other than T4 + responds to microbial antigens. Interestingly, both CAH and MPGN are

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