February 1987

HLA Immunogenetic Heterogeneity in Black American Patients With Graves' Disease

Author Affiliations

From the Thyroid Study Unit, Department of Medicine, University of Chicago (Drs Sridama, Hara, and DeGroot) and Centre Regional de Transfusion Sanguine, Rennes, France (Dr Fauchet).

Arch Intern Med. 1987;147(2):229-231. doi:10.1001/archinte.1987.00370020049034

• Seventy-three American black patients with Graves' disease were typed for HLA-A, HLA-B, and HLA-DR antigens. There was a slight increase in HLA-DRw6 antigen frequency compared with 238 normal American black controls, but this was not significant after correction for the number of antigens tested. A significant increase in HLA-DR4 and HLA-DRw6 frequency was found in a subgroup of patients with exophthalmos (22.9% and 29.2% compared with 7.6% and 10.1% of normal black controls). There was a significant increase in HLA-DRw6 in a subgroup of patients who were thyroid antibody-positive (26.0%). The increment in HLA-DRw6 was higher in 32 patients who had both exophthalmos and who were antibody positive (37.5%). A significant increase in HLA-DR5 was found in a subgroup of patients who did not have exophthalmos and who were antibody-negative (83.3%). Our findings support previous evidence for immunogenetic heterogeneity in patients with toxic Graves' disease. In American blacks HLA-DRw6 is in some way associated with the disease in contrast to the wellrecognized HLA-DR3 association in whites.

(Arch Intern Med 1987;147:229-231)