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February 1987

Efficacy and Safety of Aztreonam in the Treatment of Serious Gram-negative Bacterial Infections

Author Affiliations

From the Division of Infectious Disease, Hahnemann University, Philadelphia. Drs LeFrock and Smith are presently with the Therapeutic Research Institute, Sarasota, Fla.

Arch Intern Med. 1987;147(2):325-328. doi:10.1001/archinte.1987.00370020143052

• Aztreonam was used in the initial treatment of infection of the urinary tract (23 cases), respiratory tract (17 cases), skin and soft tissue (12 cases), abdominal cavity (three cases), endocarditis (two cases), septicemia (eight cases), and osteomyelitis (two cases). In 26 of 60 evaluable infectious episodes, aztreonam was used alone. Clinical cure was observed in 35 of 60, improvement in 24 of 60, and failure in one of 60 cases. Ten patients developed subsequent superinfection. Aztreonam was well tolerated, although one case of exfoliative dermatitis and one of pseudomembranous colitis occurred. However, these cases were complicated by proximal administration of other antibiotics.

(Arch Intern Med 1987;147:325-328)