February 1987

Paroxysmal Nocturnal Hemoglobinuria Preceding Malignant Lymphoma

Author Affiliations

From the Departments of Medicine (Dr Christou), Hematology-Oncology (Dr Subramanian), and Pathology (Dr Fung), Mercy Hospital and Medical Center, Chicago.

Arch Intern Med. 1987;147(2):377-378. doi:10.1001/archinte.1987.00370020195064

• We diagnosed lymphoma 14 months after the patient presented with paroxysmal nocturnal hemoglobinuria. To our knowledge, this is the first presentation of both conditions in a patient. One possible explanation is that both conditions could be traced to an alteration in the most primitive hemic stem cell. Such an alteration would have resulted in abnormalities of both lymphoid and nonlymphoid cell lines.

(Arch Intern Med 1987;147:377-378).