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March 1987

Update on Rifampin Drug Interactions

Author Affiliations

From the Department of Pharmacy, Bellevue Hospital, New York (Dr Baciewicz), and the Department of Clinical Pharmacy, College of Pharmacy (Dr Self) and the Division of Pulmonary Medicine, College of Medicine (Dr Bekemeyer), University of Tennessee, Memphis.

Arch Intern Med. 1987;147(3):565-568. doi:10.1001/archinte.1987.00370030169033

• Rifampin, a potent inducer of the hepatic microsomal system, has been shown to cause clinically important interactions when combined with other drugs, including oral anticoagulants, oral contraceptives, digitoxin, methadone hydrochloride, sulfonylureas, and barbiturates. Additional literature on previously described interactions has been published recently on quinidine, glucocorticoids, digoxin, and theophylline. New rifampin interactions have been described for cyclosporine, ketoconazole, chloramphenicol, β-blockers, verapamil, and phenytoin. These interactions seem to be of clinical significance.

(Arch Intern Med 1987;147:565-568)