March 1987

Recurrent Reversible Acute Renal Failure From Amphotericin

Author Affiliations

From the Nephrology Program, Pritzker School of Medicine, University of Chicago.

Arch Intern Med. 1987;147(3):593-595. doi:10.1001/archinte.1987.00370030191038

• A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure and its reversibility within days suggests that there was a functional component to the renal dysfunction. We propose that amphotericin, in the setting of reduced effective arterial volume, may activate tubuloglomerular feedback, thereby contributing to acute renal failure.

(Arch Intern Med 1987;147:593-595)