April 1987

Henoch-Schönlein Purpura Following Thiram Exposure

Author Affiliations

From the Departments of Medicine (Dr Duell) and Public Health and Preventive Medicine, Division of Environmental Medicine (Dr Morton), Oregon Health Sciences University, Portland. Dr Duell is presently with the Department of Medicine, University of Washington, Seattle.

Arch Intern Med. 1987;147(4):778-779. doi:10.1001/archinte.1987.00370040160028

• Henoch-Schönlein purpura (HSP) is an uncommon, nonthrombocytopenic hypersensitivity vasculitis that is often idiopathic, but may be induced by infectious agents, drugs, foods, environmental chemicals, or insect bites. To our knowledge, we report the first recognized case of HSP following exposure to the widely used industrial and agricultural agent, tetramethylthiuram disulfide. Few reports of HSP or other vasculitides resulting from exposure to structurally similar compounds are available. Despite the widespread use of tetramethylthiuram disulfide, many cases of exposure may remain unrecognized, resulting in a subsequent failure to properly identify sequelae.

(Arch Intern Med 1987;147:778-779)