May 1987

Factors Influencing the Incidence of Infections in Felty's Syndrome

Author Affiliations

From the Departments of Rheumatology (Drs Breedveld and Cats), Hematology (Dr Fibbe), Medical Statistics (Dr Hermans), and Infectious Diseases (Dr van der Meer), University Hospital, Leiden, the Netherlands.

Arch Intern Med. 1987;147(5):915-920. doi:10.1001/archinte.1987.00370050111019

• To identify clinical and laboratory risk factors for the susceptibility to infections in Felty's syndrome, 46 patients were studied prospectively during a total number of 431 periods of three months ("patient-quarters"). The incidence of infections increased significantly with polymorphonuclear leukocyte (PMN) counts below 0.1×103/mm3 (<0.1 ×109/L). At PMN levels over 0.1 × 103/mm3 (>0.1 ×109/L), no association was found between PMN counts and the incidence of infections. Other factors found to be associated with an increased incidence of infections were severe disability, skin ulcers, glucocorticosteroid dose, monocyte counts, hypocomplementemia, and high levels of circulating immune complexes. The activity of the rheumatoid arthritis, erythrocyte sedimentation rate, hemoglobin concentrations, and lymphocyte counts were not associated with increased incidence of infections.

(Arch Intern Med 1987;147:915-920)