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May 1987

Quantitation of Proteinuria by the Use of Protein-to-Creatinine Ratios in Single Urine Samples

Author Affiliations

From the Department of Medicine, Duke University, Durham, NC (Dr Schwab), and the Departments of Medicine (Ms Dougherty and Dr Klahr) and Laboratory Medicine (Dr Christensen), Washington University, St Louis. Dr Christensen is now with the Departments of Medical Technology and Pathology, Michigan State University, East Lansing.

Arch Intern Med. 1987;147(5):943-944. doi:10.1001/archinte.1987.00370050135022

• Measurements of protein-to-creatinine ratios in single-voided urine samples were compared with 24-hour urinary protein excretions for quantitation of proteinuria in inpatients and outpatients. Patients included those representing a broad spectrum of renal diseases, a wide range of proteinuria, and various degrees of reduction in glomerular filtration rate. Protein-to-creatinine ratios in single-voided urine samples correlated well with measurements of 24-hour urinary protein. This simple single-voided test is reliable and useful in the screening, assessment, and follow-up of proteinuria and avoids the problems associated with 24-hour urine collection.

(Arch Intern Med 1987;147:943-944)