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May 1987

Floxacillin-Induced Cholestatic Hepatitis With Evidence of Lymphocyte Sensitization

Author Affiliations

From the Department of Medicine 2, Faculty of Medicine of Lisbon, University Hospital of Santa Maria.

Arch Intern Med. 1987;147(5):987-989. doi:10.1001/archinte.1987.00370050179030

• A severe and prolonged form of biopsy-proved cholestatic hepatitis occurred in a 45-year-old man who had received floxacillin for two weeks preceding the episode of drug-related cholestatic injury. Immunologic tests revealed evidence of in vitro sensitization to the drug as well as to the serum of a normal subject collected after ingestion of floxacillin. Floxacillin should be added to the list of drugs causing cholestatic hepatitis, most likely by an immunologic mechanism.

(Arch Intern Med 1987;147:987-989)