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July 1987

Synthetic Human Calcitonin in Refractory Paget's Disease of Bone

Author Affiliations

From the Miami Veterans Administration Medical Center and the Arthritis Division, Department of Medicine, University of Miami School of Medicine.

Arch Intern Med. 1987;147(7):1305-1308. doi:10.1001/archinte.1987.00370070119017

• Fourteen patients with symptomatic and active Paget's disease of bone who had demonstrated resistance to parenteral synthetic salmon calcitonin, oral disodium etidronate, or both in combination were treated with parenteral synthetic human calcitonin. Eleven patients (79%) demonstrated clinical and chemical improvement for up to five years. Two patients received additional benefit with combined synthetic human calcitonin and etidronate disodium.

(Arch Intern Med 1987;147:1305-1308)