August 1987

Reversible Adsorption (Desorption) of Aspirin From Activated Charcoal

Author Affiliations

From the Department of Clinical Practice, Massachusetts College of Pharmacy and Allied Health Sciences (Drs Filippone, Fish, and Scavone); the Division of Clinical Pharmacology and Toxicology, The Children's Hospital (Drs Lacouture and Lovejoy); the Department of Pediatrics, Harvard Medical School (Dr Lovejoy); the Division of Clinical Pharmacology, New England Medical Center (Dr Scavone); and the Departments of Medicine and Psychiatry, Tufts University Medical School (Dr Scavone), Boston. Dr Filippone is now with Rutgers University College of Pharmacy, Piscataway, NJ; Dr Fish is with the Department of Emergency Medicine, Boston City Hospital.

Arch Intern Med. 1987;147(8):1390-1392. doi:10.1001/archinte.1987.00370080026006

• The potential desorption of aspirin from activated charcoal was investigated in eight patients in a randomized crossover study. Despite prebinding of aspirin, systemic absorption did occur. Desorption from activated charcoal was characterized by a peak salicylate concentration that was 16% of control and a time to peak salicylate concentration that was delayed in the study group. Bioavailability of aspirin from activated charcoal described by area under the curve was 19% of control. Elimination half-lives were similar in both groups until 12 hours after ingestion, but after 12 hours the half-life of the study group was prolonged while salicylate concentrations were undetectable in the control group. Fifteen percent to 20% of aspirin prebound to charcoal may desorb leading to systemic absorption. Furthermore, release from activated charcoal is initially delayed then sustained through 30 hours.

(Arch Intern Med 1987;147:1390-1392)