December 1987

Haemophilus parainfluenzae Meningitis in an Adult With an Inherited Deficiency of the Seventh Component of Complement

Author Affiliations

Marseille, France


Arch Intern Med. 1987;147(12):2214. doi:10.1001/archinte.1987.00370120150028

To the Editor.  —We describe the first case (to our knowledge) of Haemophilus parainfluenzae meningitis in a patient lacking serum complement (C7) activity. This 19-year-old woman was hospitalized in January 1986 for fever, headaches, and vomiting. Her family reported a history of nondocumented bacterial meningitis that occurred when she was 4 years of age.

Report of a Case.  —On examination we found fever (40°C), confusion, and a nuchal stickiness. Lumbar puncture on admission revealed 11300 white cells, with 0.80 (80%) polymorphonuclear leukocytes per cubic millimeter; the protein level was 1.2 g/L (120 mg/dL) and the glucose level was 0.06 g/L (1.1 mg/dL). The white blood cell count was 51.1×109/L (51100/mm3). Antibiotic therapy was started using ceftizoxime (a third-generation cephalosporin) at a dose of 2 g every eight hours administered intravenously for ten days. The patient recovered. Blood cultures remained sterile but the cerebrospinal fluid culture yielded H

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