January 1988

Paroxysmal Nocturnal Hemoglobinuria Associated With the Acquired Immunodeficiency Syndrome

Author Affiliations

From the Departments of Medicine (Drs Baumann, Pacheco, Paul, and Sorg), and Pathology (Dr Hillman), Wright State University School of Medicine and Veterans Administration Medical Center, Dayton, Ohio.

Arch Intern Med. 1988;148(1):212-213. doi:10.1001/archinte.1988.00380010214023

• Pancytopenia Is a well-recognized manifestation of clinical Illness related to human immunodeficiency virus infection. The mechanism of this has been debated, but has been thought to relate either to a nonspecific marrow suppressive effect of opportunistic infections, or to direct involvement of bone marrow hematopoietic precursors as a target of human immunodeficiency virus. We report the unique temporal association of the acquired immunodeficiency syndrome and paroxysmal nocturnal hemoglobinuria.

(Arch Intern Med 1988;148:212-213)