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Article
March 1988

Strongyloidiasis in an Institution for Mentally Retarded Adults

Author Affiliations

From the Infectious Diseases Section, Department of Medicine, Temple University Health Sciences Center, Philadelphia (Drs Braun and Fekete); and the Southampton Unit of the Philadelphia State Hospital.

Arch Intern Med. 1988;148(3):634-636. doi:10.1001/archinte.1988.00380030140024
Abstract

• A serologic and epidemiologic survey was undertaken to explain the high incidence of eosinophilia (14.1%) In nine of 64 residents of a facility for mentally retarded adults in Pennsylvania. Seven residents had antibodies to Strongyloides stercoralis as determined by an IgG enzyme-linked immunosorbent assay system (10.9%) and five (71.4%) of this subset had persistent eosinophilia, suggesting a strong association. Sex, race, age, ward, degree of retardation, and medication were not associated with eosinophilia. Stool examination revealed S stercoralis larvae in two residents with S stercoralis antibodies and eosinophilia. Follow-up studies after thiabendazole treatment of the residents with S stercoralis antibodies showed resolution of eosinophilia and disappearance of S stercoralis antibodies in most. Eosinophilia in an adult institutional setting may be associated with strongyloidiasis, even in a nonendemic area. The enzyme-linked immunosorbent assay for antibody to S stercoralis may be useful in diagnosing or monitoring therapy of strongyloidiasis.

(Arch Intern Med 1988;148:634-636)

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