June 1988

The Effects of Antihypertensive Agents on Serum Lipids and Lipoproteins

Author Affiliations

From the Veterans Administration Medical Center and Department of Medicine and Physiology, University of Nevada School of Medicine, Reno (Dr Lardinois); and the Department of Pharmaceutical Services, University of California, Davis (Ms Neuman).

Arch Intern Med. 1988;148(6):1280-1288. doi:10.1001/archinte.1988.00380060044012

• Hypertension is a major risk factor for arteriosclerotic vascular disease. Despite intensive antihypertensive Intervention, the risk of cardiovascular disease has not declined appreciably. Many of the antihypertensive agents have been shown to elevate total serum cholesterol and triglyceride levels or lower the high-density lipoprotein-cholesterol level. Thus, the antihypertensive agents chosen may negate the beneficial effects of a lower blood pressure. Our purpose is to review all available antihypertensive medications and their influence on lipoprotein metabolism. Choosing the antihypertensive therapy least likely to worsen or precipitate other known cardiovascular risk factors is important. Cost and side effect profiles must also be considered in choosing the best antihypertensive regimen for your patients.

(Arch Intern Med 1988;148:1280-1288)