June 1988

Graves' Disease and Thyroxine-Binding Globulin Deficiency

Author Affiliations

From Cattedra di Endocrinologia e Patologia Costituzionale, Universita di Parma (Italy).

Arch Intern Med. 1988;148(6):1445-1446. doi:10.1001/archinte.1988.00380060209037

• Thyroxine-binding globulin (TBG) deficiency has been frequently described in single patients and in many families. Most people with abnormal TBG concentrations are euthyroid. Cases of Graves' disease and TBG deficit have rarely been reported. We describe the case of a person with Graves' disease and TBG deficiency. Because of this condition, the patient had a misdiagnosis during part of his clinical history, and therefore underwent unnecessary therapy.

(Arch Intern Med 1988;148:1445-1446)