November 1988

Regression of Oral Hairy Leukoplakia During Zidovudine Therapy

Author Affiliations

From the Department of Medicine, Section of Infectious Disease (Drs Kessler and Benson and Ms Urbanski), and the Department of Immunology/ Microbiology (Dr Kessler), Rush-Presbyterian—St Luke's Medical Center, Chicago.

Arch Intern Med. 1988;148(11):2496-2497. doi:10.1001/archinte.1988.00380110124026

• We describe two patients with human immunodeficiency virus infection and oral hairy leukoplakia whose tongue lesions resolved on oral zidovudine therapy. During therapy, each patient had a measurable reduction in human immunodeficiency virus antigen corresponding with clinical regression of oral lesions. The clinical course suggests that zidovudine may have contributed to the resolution of these lesions either indirectly through immunologic improvement or through an antiviral effect.

(Arch Intern Med 1988;148:2496-2497)