December 1988

Transient Rheumatoid Factor Positivity in Acute Human Parvovirus B19 Infection

Author Affiliations

From the Division of Rheumatology, Department of Internal Medicine, University of Iowa College of Medicine (Drs Naides and Field), and the Veterans Administration Medical Center (Dr Field), Iowa City.

Arch Intern Med. 1988;148(12):2587-2589. doi:10.1001/archinte.1988.00380120051010

• The relationship between parvovirus B19 infection and classic rheumatoid arthritis remains to be determined. We describe two adult patients with serologically documented acute parvovirus B19 infection who presented with sudden onset of symmetric polyarthritis, skin eruption, and rheumatoid factor positivity. Rheumatoid factor positivity and symptoms resolved within five months. We conclude that a diagnosis of B19 arthropathy should be considered in any patient with recent acute or subacute onset of symmetric polyarthralgia or polyarthritis and rheumatoid factor positivity, which would otherwise suggest a diagnosis of early rheumatoid arthritis.

(Arch Intern Med 1988;148:2587-2589)