January 1989

Occupational Exposure to Organic Solvents Causing Chronic Tubulointerstitial Nephritis

Author Affiliations

From the Renal Division, Departments of Internal Medicine (Drs Narvarte and Ramirez), and the Department of Pathology (Dr Saba), James A. Haley Veterans Administration Hospital and the University of South Florida College of Medicine, Tampa, Fla.

Arch Intern Med. 1989;149(1):154-158. doi:10.1001/archinte.1989.00390010134018

• We describe a patient with a history of ulcerative colitis and long-standing occupational exposure to organic solvents. Over a follow-up period of almost four years he had progression of tubulointerstitial damage documented by two kidney biopsies. We propose that long-term exposure to organic solvents can lead to the development of chronic tubulointerstitial nephritis. We describe experimental evidence that supports our conclusion.

(Arch Intern Med 1989;149:154-158)