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April 1990

Parvovirus B19–Associated Hemophagocytic Syndrome

Author Affiliations

From the Departments of Medicine, Division of Infectious Diseases (Drs Boruchoff and Blacklow), Pathology (Drs Woda and Pihan), and Pediatrics (Drs Durbin and Burstein), University of Massachusetts Medical Center, Worcester.

Arch Intern Med. 1990;150(4):897-899. doi:10.1001/archinte.1990.00390160137028

• Parvovirus B19 is a recently described pathogen, associated with an increasing spectrum of clinical manifestations. We present the first reported case, to our knowledge, of parvovirus B19–associated hemophagocytic syndrome, in which the diagnosis of parvovirus infection was documented by the presence of B19-specific IgM and IgG antibodies. Pancytopenia resolved immediately following splenectomy and the patient recovered completely.

(Arch Intern Med. 1990;150:897-899)