• This study was designed to test whether an exercise program is additive to diet counseling in lowering elevated blood cholesterol levels. From a screened population of 1024 subjects, we randomized 66 predominantly female subjects to two intervention groups: diet counseling and diet counseling with exercise. Subjects were selected who had elevated levels of serum low-density lipoprotein cholesterol, an average or low fitness level, and a diet high in saturated fat and cholesterol. After 26 weeks of intervention, 51 subjects exhibited significant decreases in serum levels of cholesterol, high-density lipoprotein cholesterol, triglycerides, and low-density lipoprotein cholesterol. The addition of exercise to diet counseling resulted in improved aerobic capacity, losses of body fat and weight, and further nonsignificant decreases in serum cholesterol and low-density lipoprotein cholesterol levels. Since these results differ from data acquired in individuals with normal to borderline serum cholesterol levels, further studies appear indicated in hypercholesterolemic subjects, especially in women.
(Arch Intern Med. 1990;150:1016-1020)
Leighton RF, Repka FJ, Birk TJ, Lynch DJ, Bingle JF, Gohara AF, Saffran J, Weaver MT, Brewster PM, Walsh ME. The Toledo Exercise and Diet StudyResults at 26 Weeks. Arch Intern Med. 1990;150(5):1016–1020. doi:10.1001/archinte.1990.00390170066015