[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.161.178.52. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
June 1990

Does Multiple-Dose Charcoal Therapy Enhance Salicylate Excretion?

Author Affiliations

From the Departments of Pharmacology and Therapeutics (Mr Kirshenbaum and Drs Sitar and Tenenbein), Pediatrics and Child Health (Ms Mathews and Dr Tenenbein), and Medicine (Drs Sitar and Tenenbein), University of Manitoba; and the Manitoba Poison Control Centre (Dr Tenenbein), Winnipeg, Canada.

Arch Intern Med. 1990;150(6):1281-1283. doi:10.1001/archinte.1990.00390180099018
Abstract

• Multiple-dose charcoal therapy has been shown to increase the excretion of some drugs. This study assesses the effects of this intervention on salicylate excretion in the postabsorptive phase. Ten human volunteers participated in this randomized, controlled, crossover, two-limbed protocol. On two occasions each volunteer ingested 2880 mg of aspirin. During the experimental limb, 25 g of activated charcoal was ingested at 4, 6, 8, and 10 hours after drug ingestion. Pharmacokinetic data were derived from serial serum salicylate concentrations, and urinary salicylate excretion was quantified. Treatment effects were 9% and 18%, respectively. Although both are significant, they are clinically modest, making multiple-dose charcoal therapy of questionable value for acute salicylate poisoning. Controlled data demonstrating the clinical efficacy of this therapy are required to validate it as an intervention for this condition.

(Arch Intern Med. 1990;150:1281-1283)

×