July 1990

Compliance Declines Between Clinic Visits

Author Affiliations

From the Neurology Service, Veterans Affairs (VA) Medical Center, West Haven, Conn; and the Department of Neurology, Yale University School of Medicine, New Haven, Conn.

Arch Intern Med. 1990;150(7):1509-1510. doi:10.1001/archinte.1990.00390190143023

• Adherence to prescribed drug dosing regimens declined substantially during the interval between clinic visits and drug level tests. Using microelectronic monitors to observe pill-taking habits, 20 patients averaged 88% compliance before and 86% compliance after the visit, but this dropped to 67% compliance a month later. These data indicate that spot drug levels do not represent long-term "steady-state" drug serum concentrations.

(Arch Intern Med. 1990;150:1509-1510)