• Adherence to prescribed drug dosing regimens declined substantially during the interval between clinic visits and drug level tests. Using microelectronic monitors to observe pill-taking habits, 20 patients averaged 88% compliance before and 86% compliance after the visit, but this dropped to 67% compliance a month later. These data indicate that spot drug levels do not represent long-term "steady-state" drug serum concentrations.
(Arch Intern Med. 1990;150:1509-1510)
Cramer JA, Scheyer RD, Mattson RH. Compliance Declines Between Clinic Visits. Arch Intern Med. 1990;150(7):1509–1510. doi:10.1001/archinte.1990.00390190143023