September 1990

Comparison of Psyllium Hydrophilic Mucilloid and Cellulose as Adjuncts to a Prudent Diet in the Treatment of Mild to Moderate Hypercholesterolemia

Author Affiliations

From the Lipid Research Clinic, The George Washington Medical Center, Washington, DC (Drs Levin, Miller, Muesing, and LaRosa and Ms Stoy), and The Procter & Gamble Company, Cincinnati, Ohio (Mr Balm). Dr Levin is now with the Division of Cardiology, Kaiser Permanente Medical Group, Santa Clara, Calif.

Arch Intern Med. 1990;150(9):1822-1827. doi:10.1001/archinte.1990.00390200036007

• The effects of the administration of 5.1 g of psyllium or placebo (cellulose) twice daily for 16 weeks were compared as adjuncts to a prudent diet in the management of moderate hypercholesterolemia in a parallel, double-blind study. Psyllium decreased the total cholesterol level by 5.6% and the low-density lipoprotein cholesterol level by 8.6%, whereas the levels were unchanged in the placebo group. The high-density lipoprotein cholesterol level decreased during the diet stabilization period in both groups and returned to near-baseline values by week 16. Plasma triglyceride levels did not change substantially in either group. Subject compliance to treatment was greater than 95%. These data suggest that psyllium hydrophilic mucilloid in a twice-daily regimen may be a useful and safe adjunct to a prudent diet in the treatment of moderate hypercholesterolemia.

(Arch Intern Med. 1990;150:1822-1827)