September 1990

Sulbactam-Induced Hyperpyrexia

Author Affiliations

From the Departments of Surgery (Dr Olivencia-Yurvati) and Internal Medicine (Dr Sanders), Tulsa (Okla) Regional Medical Center.

Arch Intern Med. 1990;150(9):1961. doi:10.1001/archinte.1990.00390200137026

• We describe a patient who experienced hyperpyrexia after the administration of ampicillin sodium–sulbactam sodium. This previously unreported complication did not occur with administration of ampicillin alone and could not be attributed to other medications, to diluents, or to an allergic reaction. Because of the evidence in this case, we believe that the sulbactam component of this antibiotic combination should be considered in the pathogenesis of drug-induced hyperpyrexia.

(Arch Intern Med. 1990;150:1961)