September 1990

Antiphospholipid Antibodies Associated with Human Immunodeficiency Virus Infection

Author Affiliations

Nice, France

Arch Intern Med. 1990;150(9):1975. doi:10.1001/archinte.1990.00390200149037

To the Editor.—We read with interest the article by Stimmler et al1 in the August 1989 issue of the Archives concerning anticardiolipin antibodies in acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC). The conclusions were that the presence of anticardiolipin antibodies is common and is related to the underlying infection with human immunodeficiency virus.

We have recently tested 157 patients with human immunodeficiency virus antibodies for a prospective coagulation study.2 The ages of the patients ranged from 16 to 49 years, with a mean age of 28 years. The risk factors for human immunodeficiency virus infection were homosexuality in 21 patients. Intravenous drug abuse in 135 patients, and hemophilia in 1 patient. Seventy-four patients were asymptomatic (Centers for Disease Control [Atlanta, Ga], group 3), 45 were symptomatic (Centers for Disease Control group 3 and 4), and 38 have AIDS. Antiphospholipid antibodies were tested using an enzyme-linked immunosorbent

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