October 1990

Pregnancy in Women With Immune Thrombocytopenic Purpura

Author Affiliations

From the Blood Center (Drs Moutet, Duédari, and Bierling, Ms Fromont, and Mr Bettaieb) and the Department of Immunology (Drs Farcet, Duédari, and Bierling), Henri Mondor Hospital, and the Department of Obstetrics, Centre Hospitalier Intercommunal (Dr Rotten), Créteil, France.

Arch Intern Med. 1990;150(10):2141-2145. doi:10.1001/archinte.1990.00390210105023

• Thirty-six women with immune thrombocytopenic purpura were studied during 37 pregnancies, and maternal characteristics with predictive value for the fetal platelet count were determined. Nine neonates were thrombocytopenic, with a platelet count of less than 50 × 109/L in eight. Four of these nine neonates delivered to a subgroup of 31 mothers were studied prospectively; the frequency of thrombocytopenia in neonates of women with immune thrombocytopenic purpura was thus 13%. Only two of these nine neonates presented with hemorrhagic syndromes (two, petechial purpura; one, intracranial bleeding). The frequency of neonatal thrombocytopenia was higher in mothers with deep thrombocytopenia and in those who had not responded to corticosteroid treatment following diagnosis. No prognostic value could be assigned to the other maternal characteristics studied, such as a history of splenectomy, maternal treatment at the time of delivery, or the presence of platelet autoantibodies evaluated either with the platelet immunofluorescence test or the platelet Western blot immunoassay.

(Arch Intern Med. 1990;150:2141-2145)