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November 1990

Pheochromocytoma Presenting as Rhabdomyolysis and Acute Myoglobinuric Renal Failure

Author Affiliations

From the Department of Medicine, Division of Renal Diseases (Drs Shemin and Zipin), and the Department of Medicine (Dr Cohn), Rhode Island Hospital, and the Division of Biological and Medical Sciences, Brown University, Providence, RI (Drs Shemin, Cohn, and Zipin).

Arch Intern Med. 1990;150(11):2384-2385. doi:10.1001/archinte.1990.00390220118024

• We report the case of a previously healthy young woman who presented with the sudden onset of rhabdomyolysis and myoglobinuric renal failure, requiring hemodialysis for 3 weeks. Common causes of rhabdomyolysis were ruled out; as renal function returned, severe hypertension was noted and a pheochromocytoma was diagnosed. We suggest that pheochromocytoma causes rhabdomyolysis and myoglobinuria via catecholamine-mediated vasoconstriction and skeletal muscle ischemia.

(Arch Intern Med. 1990;150:2384-2385)