April 1991

Cyclic Antidepressants and the Risk of Hip Fracture

Author Affiliations

Edith Malcolm

From the Division of Pharmacoepidemiology, Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tenn (Drs Ray and Griffin); and the Laboratory and Disease Control Services Branch, Saskatchewan Health, Regina (Ms Malcolm).

Arch Intern Med. 1991;151(4):754-756. doi:10.1001/archinte.1991.00400040096021

To determine whether cyclic antidepressants increase the risk of hip fracture, we conducted a population-based casecontrol study in the Canadian province of Saskatchewan. We identified 4501 persons 65 years of age or older with a first hospitalization for hip fracture between 1977 and 1985 and 24 041 comparable controls. Current antidepressant users had a relative risk of hip fracture of 1.6 (95% confidence interval, 1.3 to 1.9). Medical record review for a sample of 164 cases suggested this finding was not due to confounding by body mass, impaired ambulation, functional status, or dementia.

(Arch Intern Med. 1991;151:754-756)