[Skip to Content]
[Skip to Content Landing]
April 1991

Lyme Test Problems-Reply

Author Affiliations

Old Lyme, Conn

Arch Intern Med. 1991;151(4):816. doi:10.1001/archinte.1991.00400040143039

In Reply. —  Dr Cameron brings up two points that were not discussed in our article.1 His supposition that the university laboratory (laboratory E) that detected antibodies to Borrelia burgdorferi in 100% of the specimens was also our reference laboratory is incorrect. In fact, laboratory E was not the laboratory used in the initial serodiagnosis of any of the patients (because they do not routinely test for separate IgG and IgM antibodies). Rather, laboratories F and G had confirmed the seropositivity of these patients at dates prior to obtaining the study specimens. In addition, the conclusion of the study was not that laboratory E obtained the correct response, but, rather, that there was marked variability in the sensitivity of laboratories in detecting antibodies to B burgdorferi on the same specimens.Cameron's statement that the article was "misleading in not commenting on serologic testing" in patients who are seronegative but

First Page Preview View Large
First page PDF preview
First page PDF preview