August 1991

Accuracy of Cholesterol Measurements-Reply

Author Affiliations

Kansas City, Kan

Arch Intern Med. 1991;151(8):1677. doi:10.1001/archinte.1991.00400080155043

In Reply.—  It has been appropriately pointed out by Bock that a 5% deviation from "true" value may be too restrictive, especially when only one or two samples are being evaluated at a reference and at a clinical laboratory. The value of 9.5% recommended by the National Cholesterol Education Program is perhaps more practical and allows for each laboratory to be within 5% of the target value. We used the 5% figure in the editorial1 because we believed that if a series of cross-checked samples is consistently more than 5% off of the true value (Centers for Disease Control laboratory value), then something is wrong in the laboratory being evaluated. We appreciate Bock's comments on this point.

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