November 1991

A Case of Propylene Glycol Toxic Reaction Associated With Etomidate Infusion

Author Affiliations

From the Division of Nephrology, Department of Medicine, Medical College of Virginia, Richmond.

Arch Intern Med. 1991;151(11):2297-2298. doi:10.1001/archinte.1991.00400110137026

For the treatment of postoperative seizures and prevention of brain edema, an etomidate drip was used in conjunction with phenytoin, diazepam, pentobarbital, and phenobarbital in a 70-year-old woman. During a period of 24 hours, the patient received in excess of 479 g of propylene glycol, which was present at 35% (vol/vol) concentration in the undiluted etomidate. The propylene glycol toxic reaction resolved after the infusion was stopped.

(Arch Intern Med. 1991;151:2297-2298)