The alternative explanations given by Denker regarding normal radioiodine uptake in our patient with thyrotoxicosis induced by topical iodine application1 is entirely plausible. However, the temporal relationship between iodine application and subsequent onset of clinical hyperthyroidism tends to favor iodine-induced thyrotoxicosis.The point we want to emphasize in our article is that povidone-iodine soaks are commonly used in the treatment of pressure sores and caution is necessary when used in patients with thyroid disorders, because they may cause abnormal thyroid hormone secretion or difficulty in interpreting the results of thyroid function tests, especially radioiodine uptake.
Shetty KR, Duthie EH. Hyperthyroidism With a Low Radioactive Iodine Uptake-Reply. Arch Intern Med. 1991;151(11):2330. doi:10.1001/archinte.1991.00400110148038