February 1992

Amantadine-Resistant Influenza A in a Nursing Facility

Author Affiliations

From the Section of Geriatric Medicine, Department of Internal Medicine (Drs Degelau and Crossley), and the Section of Clinical Pharmacy (Drs Somani, Guay, and Ms Cooper), St Paul-Ramsey Medical Center, St Paul, Minn.

Arch Intern Med. 1992;152(2):390-392. doi:10.1001/archinte.1992.00400140128027

Rapid index case treatment and amantadine prophylaxis were implemented in two nursing homes exposed to influenza A. Facility A had no isolation of cases, and 18 of 22 cases occurred after amantadine hydrochloride therapy was initiated. Three patients exhibited amantadine-resistant virus. Facility B had day 1 isolation of the index case. A facility-wide outbreak did not occur. The experience of these facilities suggests that concurrent amantadine treatment and prophylaxis without adequate case isolation may promote further influenza A infection in a nursing facility.

(Arch Intern Med. 1992;152:390-392)