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March 1992

Passive Transfer of Antibody to Hepatitis C

Author Affiliations

Atlanta, Ga

Arch Intern Med. 1992;152(3):639-640. doi:10.1001/archinte.1992.00400150143027

To the Editor.—  Passive transfer of antibodies is the usual reason for administering immune serum globulin (ISG). However, the transfer of undesired antibodies may cause concern, especially if a history of recent ISG administration is not elicited prior to serologic testing. Since antigen assays for several viral pathogens are not commercially available, antibody testing must answer critical questions in many situations.Health care workers are especially liable to repeated exposures to blood and body fluids, and thus many courses of ISG can occur. In response to a recent article1 regarding passive transfer of the hepatitis C virus (HCV) antibody by intravenous administration of ISG, we wish to report a case of documented transient seroconversion to anti-HCV positivity following an intramuscular dose of ISG in a health care worker.

Report of a Case.—  On November 30, 1990, a healthy 38-year-old Emory University Hospital housekeeping employee splashed blood from a trash

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