July 12, 1993

Invasive Sinusitis With Intracranial Extension Caused by Curvularia lunata

Author Affiliations

From the Department of Medicine, Kern Medical Center, UCLA School of Medicine, Bakersfield. Dr Ismail is a Cardiology Research Fellow at Central California Heart Institute, Bakersfield.

Arch Intern Med. 1993;153(13):1604-1606. doi:10.1001/archinte.1993.00410130126013

Curvularia lunata has previously been linked to localized sinus infection in immunocompetent hosts. We treated a case of pansinusitis with extensive bone destruction and intracranial extension caused by C lunata. Curvularia lunata was identified when typical fungal macroconidia appeared on culture. Numerous surgical procedures, in addition to a 12-month course of antifungal therapy consisting of 4 g of intravenous amphotericin B and an 8-month course of 400 mg of oral ketoconazole daily, were required to control the infection. This unusual case of invasive sinusitis caused by C lunata alerts the treating physician to the presence of this mold and gives an overview of diagnostic method as well as the management.

(Arch Intern Med. 1993;153:1604-1606)