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Article
July 12, 1993

Invasive Sinusitis With Intracranial Extension Caused by Curvularia lunata

Author Affiliations

From the Department of Medicine, Kern Medical Center, UCLA School of Medicine, Bakersfield. Dr Ismail is a Cardiology Research Fellow at Central California Heart Institute, Bakersfield.

Arch Intern Med. 1993;153(13):1604-1606. doi:10.1001/archinte.1993.00410130126013
Abstract

Curvularia lunata has previously been linked to localized sinus infection in immunocompetent hosts. We treated a case of pansinusitis with extensive bone destruction and intracranial extension caused by C lunata. Curvularia lunata was identified when typical fungal macroconidia appeared on culture. Numerous surgical procedures, in addition to a 12-month course of antifungal therapy consisting of 4 g of intravenous amphotericin B and an 8-month course of 400 mg of oral ketoconazole daily, were required to control the infection. This unusual case of invasive sinusitis caused by C lunata alerts the treating physician to the presence of this mold and gives an overview of diagnostic method as well as the management.

(Arch Intern Med. 1993;153:1604-1606)

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