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April 25, 1994

Antiphospholipid Antibody Syndrome Mimicking Multiple Sclerosis Clinically and by Magnetic Resonance Imaging

Author Affiliations

From the Department of Neurology, Medical College of Pennsylvania, Allegheny General Hospital, Pittsburgh (Drs Scott and Brillman); and Department of Neurology, Veterans Affairs Medical Center, Medical College of Georgia, Augusta (Dr Hess).

Arch Intern Med. 1994;154(8):917-920. doi:10.1001/archinte.1994.00420080127013

The antiphospholipid antibody syndrome, frequently seen in young individuals, is often associated with transient ischemic attacks or strokes. In some cases, this syndrome may be difficult to distinguish from exacerbating and remitting multiple sclerosis. We report four such cases. In addition, the finding of hyperintense signals on magnetic resonance imaging in multiple sclerosis may also be seen in the antiphospholipid antibody syndrome, as demonstrated in these cases. Small strokes that affect the white matter in the antiphospholipid antibody syndrome may be misdiagnosed as multiple sclerosis.

(Arch Intern Med. 1994;154:917-920)