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July 11, 1994

Rifampin-Induced Nonresponsiveness of Giant Cell Arteritis to Prednisone Treatment

Author Affiliations

From the Internal Medicine Service (Drs Carrie, P. Roblot, F. Roblot, and Becq-Giraudon) and Pharmacokinetics Laboratory (Drs Bouquet and Delon), University Hospital La Milétrie, Poitiers, France.

Arch Intern Med. 1994;154(13):1521-1524. doi:10.1001/archinte.1994.00420130119015

Rifampin is an enzymatic inducer known to increase steroid metabolism. We studied two patients with giant cell arteritis in whom rifampin caused nonresponsiveness to prednisone treatment. A prednisolone pharmacokinetics study was done. When rifampin-prednisone treatment must be used in giant cell arteritis, we propose increasing the prednisone dosage to 2 mg/kg per day.

(Arch Intern Med. 1994;154:1521-1524)