Rifampin is an enzymatic inducer known to increase steroid metabolism. We studied two patients with giant cell arteritis in whom rifampin caused nonresponsiveness to prednisone treatment. A prednisolone pharmacokinetics study was done. When rifampin-prednisone treatment must be used in giant cell arteritis, we propose increasing the prednisone dosage to 2 mg/kg per day.
(Arch Intern Med. 1994;154:1521-1524)
Carrie F, Roblot P, Bouquet S, Delon A, Roblot F, Becq-Giraudon B. Rifampin-Induced Nonresponsiveness of Giant Cell Arteritis to Prednisone Treatment. Arch Intern Med. 1994;154(13):1521-1524. doi:10.1001/archinte.1994.00420130119015