August 22, 1994

Catamenial Insulin Reactions Treated With a Long-Acting Gonadotropin Releasing Hormone Agonist

Author Affiliations

From the Reproductive Endocrinology Service, Department of Obstetrics and Gynecology (Dr Letterie) and the Medical Endocrinology Service, Department of Medicine (Dr Fredlund), Virginia Mason Medical Center, Seattle, Wash.

Arch Intern Med. 1994;154(16):1868-1870. doi:10.1001/archinte.1994.00420160108015

Exacerbation of a variety of symptoms during the menstrual cycle is a well-described phenomenon. The exact causes of these changes are poorly understood, and no specific and efficacious therapy has been described. We successfully treated a patient with severe catamenial insulin reactions with a long-acting gonadotropin releasing hormone agonist to suppress menstrual function and added a combination of estrogen and progestin to offset any adverse effect of the resultant hypoestrogenemia for 1 year.

(Arch Intern Med. 1994;154:1868-1870)