Exacerbation of a variety of symptoms during the menstrual cycle is a well-described phenomenon. The exact causes of these changes are poorly understood, and no specific and efficacious therapy has been described. We successfully treated a patient with severe catamenial insulin reactions with a long-acting gonadotropin releasing hormone agonist to suppress menstrual function and added a combination of estrogen and progestin to offset any adverse effect of the resultant hypoestrogenemia for 1 year.
(Arch Intern Med. 1994;154:1868-1870)
Letterie GS, Fredlund PN. Catamenial Insulin Reactions Treated With a Long-Acting Gonadotropin Releasing Hormone Agonist. Arch Intern Med. 1994;154(16):1868-1870. doi:10.1001/archinte.1994.00420160108015