In regard to DiNubile's editorial concerning acute fevers of unknown origin that appeared in the November 22, 1993, issue of the Archives,1 I believe that almost all causes that were listed therein, with the exception of pancreatitis and hepatitis, were likewise listed as causes of hyperthermia.2,3 For that reason, I do not see the need to create a separate syndrome of "acute fevers of unknown origin" nor do I believe there is a need to be emphatic about not using antibiotics to treat them empirically.
Anceno-Reyes RI. Acute Fevers of Unknown Origin. Arch Intern Med. 1994;154(19):2253-2254. doi:10.1001/archinte.1994.00420190157020