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Article
April 24, 1995

Death of a Young Woman Suffering From Primary Pulmonary Hypertension During Inhaled Nitric Oxide Therapy

Author Affiliations

Helsinki, Finland

Arch Intern Med. 1995;155(8):875-876. doi:10.1001/archinte.1995.00430080125018
Abstract

Primary pulmonary hypertension is an often fatal disease of mostly young women. Inhaled nitric oxide decreases high pulmonary vascular resistance due to various causes and decreases pulmonary blood pressure.1-4 Nitric oxide has been used as a form

of treatment for primary pulmonary hypertension4 We had an unfortunate experience with this form of treatment.

Report of a Case.  A 22-year-old woman had suffered from primary pulmonary hypertension for the past 3 years. When last seen, she had dyspnea at rest, but had refused transplantation. It was decided to use nitric oxide as a form of treatment.Pulmonary and radial artery catheters were inserted. Fifteen hours later, inhaled nitric oxide therapy (5 parts per million [ppm]) was started. The inhaled nitrogen dioxide concentration remained at 0.1 to 0.5 ppm. The hemodynamic parameters taken before the administration of nitric oxide and at 6 and 9 hours after administration are given in the Table.

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